{"product_id":"kisspeptin","title":"Kisspeptin","description":"\u003ch2\u003eKisspeptin Research Peptide\u003c\/h2\u003e\u003cp\u003eKisspeptin is available for laboratory research, with the current product description identifying the Kisspeptin-10 form. Confirm the presentation and available batch information against the exact material specified for your work.\u003c\/p\u003e\u003ch3\u003eProduct information\u003c\/h3\u003e\u003cp\u003eSelect from the presentations shown on this page. For a specific batch or analytical requirement, contact \u003ca href=\"mailto:support@bulkpeptides.org\"\u003esupport@bulkpeptides.org\u003c\/a\u003e for available product documentation before ordering.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"\/pages\/kisspeptin-research-guide\"\u003eRead the Kisspeptin research guide\u003c\/a\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFor laboratory research use only.\u003c\/strong\u003e Not for human or veterinary use, diagnosis, treatment, or clinical application.\u003c\/p\u003e\u003csection class=\"product-research-information\"\u003e\u003ch2\u003eProduct research information\u003c\/h2\u003e\n\u003cp\u003eKisspeptin-10 possesses the molecular formula \u003cstrong\u003eC₆₃H₇₈N₁₈O₁₄\u003c\/strong\u003e and consists of a chain of 10 amino acids. It is derived from the KISS1 gene, which encodes a larger precursor protein known as metastin. This specific fragment is chemically synthesized to retain the bioactive carboxyl-terminal sequence required for receptor binding affinity in laboratory settings.\u003c\/p\u003e\n\u003cp\u003eThe primary mechanism of action explored in scientific literature involves the binding of Kisspeptin-10 to the GPR54 receptor. Upon activation, this receptor initiates intracellular signaling cascades involving phospholipase C and calcium mobilization. Studies suggest that this signaling pathway is critical for the depolarization of GnRH neurons, thereby influencing the pulsatile secretion of downstream hormones such as Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH).\u003c\/p\u003e\n\u003cp\u003eIn animal models, Kisspeptin-10 is frequently utilized to study the onset of puberty and the regulation of reproductive feedback loops. Research indicates that the peptide may play a pivotal role in metabolic status and reproductive function connection. Investigators also examine the sensitivity of the GPR54 receptor to desensitization following continuous exposure to the ligand in vitro.\u003c\/p\u003e\n\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003eGottsch, M. L., et al. (2004). “A role for kisspeptins in the regulation of gonadotropin secretion in the mouse.” \u003cem\u003eEndocrinology\u003c\/em\u003e, 145(9), 4073-4077.\u003c\/li\u003e\n\u003cli\u003eOakley, A. E., et al. (2009). “Kisspeptin Signaling in the Brain.” \u003cem\u003eEndocrine Reviews\u003c\/em\u003e, 30(6), 713–743.\u003c\/li\u003e\n\u003cli\u003eKotani, M., et al. (2001). “The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.” \u003cem\u003eJournal of Biological Chemistry\u003c\/em\u003e, 276(36), 34631-34636.\u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/section\u003e","brand":"Bulk Peptides","offers":[{"title":"10 MG","offer_id":51303542620327,"sku":"KISS10MG","price":65.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0770\/0384\/9895\/files\/kisspeptin.png?v=1788658194","url":"https:\/\/bulkpeptides.org\/products\/kisspeptin","provider":"Bulk Peptides","version":"1.0","type":"link"}