{"product_id":"kpv","title":"KPV","description":"\u003ch2\u003eKPV Research Peptide\u003c\/h2\u003e\u003cp\u003eKPV is offered as a peptide material for controlled laboratory investigations. The research library provides a referenced overview of KPV terminology and published evidence, separate from the specifications of the product being supplied.\u003c\/p\u003e\u003ch3\u003eProduct information\u003c\/h3\u003e\u003cp\u003eSelect from the presentations shown on this page. For a specific batch or analytical requirement, contact \u003ca href=\"mailto:support@bulkpeptides.org\"\u003esupport@bulkpeptides.org\u003c\/a\u003e for available product documentation before ordering.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"\/pages\/kpv-research-guide\"\u003eRead the KPV research guide\u003c\/a\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFor laboratory research use only.\u003c\/strong\u003e Not for human or veterinary use, diagnosis, treatment, or clinical application.\u003c\/p\u003e\u003csection class=\"product-research-information\"\u003e\u003ch2\u003eProduct research information\u003c\/h2\u003e\n\u003cp\u003eKPV is a naturally occurring tripeptide fragment with the molecular formula \u003cstrong\u003eC₁₆H₃₀N₄O₄\u003c\/strong\u003e. It corresponds to the specific amino acid sequence Lys-Pro-Val. This sequence is derived from alpha-Melanocyte Stimulating Hormone (α-MSH), a peptide known for its role in pigmentation and energy homeostasis. However, the KPV fragment is distinct in that it does not bind to the melanocortin receptors responsible for melanogenesis, allowing researchers to study its anti-inflammatory potential in isolation.\u003c\/p\u003e\n\u003cp\u003eScientific studies focus on KPV’s ability to modulate the NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling pathway. In laboratory models, KPV has been observed to translocate into cells via the PepT1 peptide transporter, where it may downregulate the expression of pro-inflammatory cytokines. This mechanism is of particular interest in research regarding Inflammatory Bowel Disease (IBD) and colitis.\u003c\/p\u003e\n\u003cp\u003eAdditionally, KPV is investigated for its antimicrobial activity. Studies suggest that the peptide may disrupt the structural integrity of fungal and bacterial membranes. In dermatological research, KPV is utilized to examine wound healing rates and the reduction of contact dermatitis, promoting the study of peptide-based modulation of the host immune response without the side effects associated with steroidal compounds.\u003c\/p\u003e\n\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003eDalmasso, G., et al. (2008). “PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.” \u003cem\u003eGastroenterology\u003c\/em\u003e, 134(1), 166-178.\u003c\/li\u003e\n\u003cli\u003eBrzoska, T., et al. (2008). “Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo.” \u003cem\u003eEndocrine Reviews\u003c\/em\u003e, 29(5), 581-602.\u003c\/li\u003e\n\u003cli\u003eLuger, T. A., et al. (2003). “The role of alpha-melanocyte-stimulating hormone in cutaneous biology.” \u003cem\u003eJournal of Investigative Dermatology Symposium Proceedings\u003c\/em\u003e, 8(1), 45-52.\u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/section\u003e","brand":"Bulk Peptides","offers":[{"title":"10 MG","offer_id":51303543177383,"sku":"KPV10MG","price":70.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0770\/0384\/9895\/files\/kpv.png?v=1788658061","url":"https:\/\/bulkpeptides.org\/products\/kpv","provider":"Bulk Peptides","version":"1.0","type":"link"}