{"product_id":"melanotan-1-mt-1","title":"Melanotan 1 (MT-1)","description":"\u003ch2\u003eMelanotan 1 (MT-1) Research Peptide\u003c\/h2\u003e\u003cp\u003eMelanotan 1 (MT-1) is available as a peptide material for controlled laboratory research. Use the product listing and available batch information to assess its suitability for your research requirements.\u003c\/p\u003e\u003ch3\u003eProduct information\u003c\/h3\u003e\u003cp\u003eSelect from the presentations shown on this page. For a specific batch or analytical requirement, contact \u003ca href=\"mailto:support@bulkpeptides.org\"\u003esupport@bulkpeptides.org\u003c\/a\u003e for available product documentation before ordering.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"\/pages\/melanotan-1-research-guide\"\u003eRead the Melanotan 1 (MT-1) research guide\u003c\/a\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFor laboratory research use only.\u003c\/strong\u003e Not for human or veterinary use, diagnosis, treatment, or clinical application.\u003c\/p\u003e\u003csection class=\"product-research-information\"\u003e\u003ch2\u003eProduct research information\u003c\/h2\u003e\n\u003cp\u003eMelanotan 1 (MT-1), also known in scientific literature as afamelanotide, possesses the molecular formula \u003cstrong\u003eC₇₈H₁₁₁N₂₁O₁₉\u003c\/strong\u003e. It is structurally comprised of a linear chain of 13 amino acids. Unlike the cyclic structure of Melanotan 2 (MT-2), MT-1 more closely mirrors the native structure of α-MSH, albeit with specific amino acid substitutions designed to resist rapid enzymatic degradation and extend its stability in laboratory assays.\u003c\/p\u003e\n\u003cp\u003eScientific studies focus predominantly on the interaction between MT-1 and the melanocortin 1 receptor (MC1R), which is located on the surface of melanocytes. Upon binding, MT-1 activates the adenylyl cyclase signaling pathway, subsequently increasing intracellular levels of cyclic AMP (cAMP). This cascade triggers the upregulation of the microphthalmia-associated transcription factor (MITF), a crucial step that promotes the expression of tyrosinase and drives the synthesis of melanin (melanogenesis).\u003c\/p\u003e\n\u003cp\u003eIn research models, MT-1 is utilized to study isolated pigmentation pathways without the confounding variables associated with central nervous system stimulation. Because MT-1 exhibits significantly lower binding affinity for central melanocortin receptors (such as MC3R and MC4R) compared to MT-2, researchers use it to examine cellular photoprotection, DNA repair mechanisms in skin cell cultures, and the extracellular matrix response to simulated solar damage.\u003c\/p\u003e\n\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003eHadley, M. E., \u0026amp; Dorr, R. T. (2006). “Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization.” \u003cem\u003ePeptides\u003c\/em\u003e, 27(4), 921-930.\u003c\/li\u003e\n\u003cli\u003eAbdel-Malek, Z. A., et al. (2006). “Alpha-MSH tripeptide analogs activate the melanocortin 1 receptor and reduce UV-induced DNA damage in human melanocytes.” \u003cem\u003ePigment Cell Research\u003c\/em\u003e, 19(5), 428-434.\u003c\/li\u003e\n\u003cli\u003eEberle, A. N., et al. (1991). “Melanocyte-stimulating hormone: structure-activity relationships, receptor binding and signal transduction.” \u003cem\u003eJournal of Receptor Research\u003c\/em\u003e, 11(1-4), 311-322.\u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/section\u003e","brand":"Bulk Peptides","offers":[{"title":"10 MG","offer_id":51303542161575,"sku":null,"price":55.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0770\/0384\/9895\/files\/melanotan-1-mt-1.png?v=1788657752","url":"https:\/\/bulkpeptides.org\/products\/melanotan-1-mt-1","provider":"Bulk Peptides","version":"1.0","type":"link"}