{"product_id":"melanotan-2-mt-2","title":"Melanotan 2 (MT-2)","description":"\u003ch2\u003eMelanotan 2 (MT-2) Research Peptide\u003c\/h2\u003e\u003cp\u003eMelanotan 2 (MT-2) is offered for laboratory and analytical research. It is a separate catalog material from Melanotan 1; confirm the exact identity and presentation specified by your project before ordering.\u003c\/p\u003e\u003ch3\u003eProduct information\u003c\/h3\u003e\u003cp\u003eSelect from the presentations shown on this page. For a specific batch or analytical requirement, contact \u003ca href=\"mailto:support@bulkpeptides.org\"\u003esupport@bulkpeptides.org\u003c\/a\u003e for available product documentation before ordering.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"\/pages\/melanotan-2-research-guide\"\u003eRead the Melanotan 2 (MT-2) research guide\u003c\/a\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFor laboratory research use only.\u003c\/strong\u003e Not for human or veterinary use, diagnosis, treatment, or clinical application.\u003c\/p\u003e\u003csection class=\"product-research-information\"\u003e\u003ch2\u003eProduct research information\u003c\/h2\u003e\n\u003cp\u003eMelanotan 2 (MT-2) is a synthetic analogue of the naturally occurring alpha-Melanocyte Stimulating Hormone (α-MSH) with the molecular formula \u003cstrong\u003eC₅₀H₆₉N₁₅O₉\u003c\/strong\u003e. Structurally, it is an octapeptide characterized by a lactam bridge that creates a cyclic configuration. This cyclic structure is designed to increase metabolic stability and prolong the biological half-life of the peptide against enzymatic degradation in laboratory environments compared to the linear endogenous hormone.\u003c\/p\u003e\n\u003cp\u003eScientific studies focus heavily on the interaction between MT-2 and the melanocortin 1 receptor (MC1R). Upon activation of MC1R in cellular models, the peptide stimulates adenylyl cyclase, leading to an increase in intracellular cAMP. This signaling cascade upregulates the transcription factor MITF, which promotes the expression of tyrosinase and the subsequent synthesis of melanin (melanogenesis) within melanocyte cultures.\u003c\/p\u003e\n\u003cp\u003eBeyond pigmentation, MT-2 is investigated for its high binding affinity to central melanocortin receptors, specifically MC3R and MC4R. In murine models, activation of these neural pathways is utilized to study the central regulation of energy homeostasis, specifically assessing reductions in food intake and changes in basal energy expenditure. Additionally, the peptide’s interaction with the MC4R pathway is frequently examined in research regarding erectile function and the central nervous system mechanisms governing arousal.\u003c\/p\u003e\n\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003eDorr, R. T., et al. (1996). “Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.” \u003cem\u003eLife Sciences\u003c\/em\u003e, 58(20), 1777-1784.\u003c\/li\u003e\n\u003cli\u003eHadley, M. E., \u0026amp; Dorr, R. T. (2006). “Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization.” \u003cem\u003ePeptides\u003c\/em\u003e, 27(4), 921-930.\u003c\/li\u003e\n\u003cli\u003eWessells, H., et al. (2000). “Melanocortin receptor subtypes involved in penile erection.” \u003cem\u003eJournal of Endocrinology\u003c\/em\u003e, 167(1), 17-24.\u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/section\u003e","brand":"Bulk Peptides","offers":[{"title":"10 MG","offer_id":51303542194343,"sku":null,"price":55.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0770\/0384\/9895\/files\/melanotan-2-mt-2.png?v=1788657799","url":"https:\/\/bulkpeptides.org\/products\/melanotan-2-mt-2","provider":"Bulk Peptides","version":"1.0","type":"link"}