{"product_id":"slu-pp332","title":"SLU PP332","description":"\u003ch2\u003eSLU-PP-332 Research Compound\u003c\/h2\u003e\u003cp\u003eSLU-PP-332 is offered as a laboratory research compound. It is a small-molecule material rather than an amino-acid peptide; use its product-specific information when reviewing the catalog for your experiment.\u003c\/p\u003e\u003ch3\u003eProduct information\u003c\/h3\u003e\u003cp\u003eSelect from the presentations shown on this page. For a specific batch or analytical requirement, contact \u003ca href=\"mailto:support@bulkpeptides.org\"\u003esupport@bulkpeptides.org\u003c\/a\u003e for available product documentation before ordering.\u003c\/p\u003e\u003cp\u003e\u003ca href=\"\/pages\/slu-pp-332-research-guide\"\u003eRead the SLU PP332 research guide\u003c\/a\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFor laboratory research use only.\u003c\/strong\u003e Not for human or veterinary use, diagnosis, treatment, or clinical application.\u003c\/p\u003e\u003csection class=\"product-research-information\"\u003e\u003ch2\u003eProduct research information\u003c\/h2\u003e\n\u003cp\u003eSLU-PP-332 is a synthetic compound with the molecular formula \u003cstrong\u003eC₁₈H₁₄N₂O₂\u003c\/strong\u003e. It is distinct from amino acid-based peptides, functioning instead as a direct nuclear receptor agonist. It was developed to probe the physiological roles of Estrogen-Related Receptors (ERRs), which are orphan nuclear receptors involved in the regulation of cellular energy metabolism.\u003c\/p\u003e\n\u003cp\u003ePrimary research focuses on the interaction between SLU-PP-332 and the ERRα, ERRβ, and ERRγ receptors. Upon binding, SLU-PP-332 is observed to stabilize the active conformation of these receptors, promoting the recruitment of coactivators such as PGC-1α (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha).\u003c\/p\u003e\n\u003cp\u003eIn laboratory studies involving murine models, SLU-PP-332 has been investigated for its ability to enhance mitochondrial respiration. Data indicates that the compound may upregulate the expression of genes associated with oxidative phosphorylation and fatty acid metabolism. Researchers have noted that administration in mice resulted in an increase in type IIa oxidative muscle fibers, leading to the classification of this compound as an “exercise mimetic” in scientific literature.\u003c\/p\u003e\n\u003cp\u003eFurther investigation suggests that SLU-PP-332 may influence lipid metabolism. Studies utilizing diet-induced obese mice have observed changes in energy expenditure and fat mass accumulation without alterations in food intake or physical activity levels. These findings suggest a potential pathway for modulating metabolic profiles through direct receptor activation.\u003c\/p\u003e\n\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003eBillon, C., et al. (2023). “Synthetic ERRα\/β\/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity.” \u003cem\u003eACS Chemical Biology\u003c\/em\u003e, 18(4), 756-771. \u003ca href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.3c00205\" target=\"_blank\"\u003e\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eBillon, C., et al. (2024). “A Synthetic ERR Agonist Alleviates Metabolic Syndrome.” \u003cem\u003eJournal of Pharmacology and Experimental Therapeutics\u003c\/em\u003e, 388(2), 232-240. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37739818\/\" target=\"_blank\"\u003e\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eFan, W., \u0026amp; Evans, R. M. (2015). “Exercise Mimetics: Impact on Health and Performance.” \u003cem\u003eCell Metabolism\u003c\/em\u003e, 22(3), 399-413. \u003ca href=\"https:\/\/www.cell.com\/cell-metabolism\/fulltext\/S1550-4131(15)00393-2\" target=\"_blank\"\u003e\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/section\u003e","brand":"Bulk Peptides","offers":[{"title":"5 MG","offer_id":51303542587559,"sku":"SLUPP33210","price":50.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0770\/0384\/9895\/files\/slu-pp332.png?v=1788657802","url":"https:\/\/bulkpeptides.org\/products\/slu-pp332","provider":"Bulk Peptides","version":"1.0","type":"link"}